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pentobarbital will reduce the extent or result of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Pitolisant exposure is diminished by fifty% if coadministered with strong CYP3A4 inducers.pentobarbital will lower the extent or outcome of bosentan by influencing hepatic/intestinal enzyme CYP3A4 m